Polio Antivirals Initiative
Chronic prolonged excretion of vaccine-derived polioviruses by immunodeficient persons (iVDPV) exposed to the live oral polio vaccine presents a personal risk of poliomyelitis to the patient as well as a programmatic risk to global eradication.
Poliovirus antiviral drugs offer the only mitigation of these risks. Efforts to discover and develop poliovirus antiviral agents have been ongoing since the formation in 2007 of the Poliovirus Antivirals Initiative (PAI). PAI is a collaborative project among the Bill & Melinda Gates Foundation, the World Health Organization (WHO), the Centers for Disease Control and Prevention (CDC), National Institutes of Health, Rotary International, the Food and Drug Administration, and the Jeffrey Modell Foundation. The Task Force serves as the PAI secretariat.
Two antivirals working by different mechanisms of action are currently under development by ViroDefense Inc.. The development work is funded by the Bill & Melinda Gates Foundation. The most advanced antiviral, pocapavir (V-073), is a capsid inhibitor that has demonstrated activity in an oral poliovirus vaccine human challenge model and in the compassionate use treatment of immune deficient iVDPV excreters. The second antiviral, V-7404, is a virus specific protease inhibitor that is presently being studied in a Phase 1 clinical study. The goal is to have two antivirals available for use in combination to treat iVDPV to increase efficacy and reduce the potential for drug resistance to develop. In addition to antiviral development, PAI is also working with PATH to develop a point of care diagnostic that will help identify immune deficient people.
Eight new studies will assess the impact of collaborative planning to maximize health campaigns, with funding from The Task Force’s Health Campaign Effectiveness (HCE) program.
Introducing New Vaccine for Polio Eradication: Q&A with Task Force Senior Epidemiologist Victor Eboh
The global polio eradication effort is moving one step closer to success with the upcoming rollout of a new vaccine, the novel oral polio vaccine
Polio eradication efforts reached a historic goal recently when Africa was certified as free of wild poliovirus. To mark this milestone, two Task Force polio